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Using the train is a fantastic way to travel from Motherwell to Manchester Piccadilly - with no worries about traffic, you can just sit back and enjoy your journey. Plus, booking with TransPennine Express means plenty of great value fares and no booking fees... So, book your tickets from Motherwell to Manchester Piccadilly with us today and we could help you save money on your train fare. Please note that part or all of the Motherwell to Manchester Piccadilly service may or may not be operated by TransPennine Express and a connection may be required.Buy tickets